Answer: Even when you send a legitimate email message there are great chances it will be checked by your server, the recipient server, or both of them.
Nowadays it is a common practice for system administrators to use spam checking and anti-virus software directly on their email servers. The idea is to eliminate or reduce the relaying of spam messages and the spreading of viruses thru the emailing system.
On one hand, checking messages at the server level can drastically reduce the amount of junk that will end up in your mailbox but on the other hand, that system is far from being perfect and as a result, legitimate emails will also get caught and will never get delivered. Such messages are called 'False Positives'. On average, 15% of legitimate messages do not get through to the inbox because of the false positive problem, and the rate is increasing along with the volume of spam.
We have created a document that briefly delineates a number of measures to keep your spam score as low as possible and to enhance the chances of reaching the inbox of your subscribers. It is available here: How to avoid a message from being flagged as spam.
I also recommend you to watch this short video about this topic:
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