I believe so, yes.
My ISP said it was because I was sending via them (using Authentication), but using a different from and reply to address.
I don't believe this is the case though, as that is exactly how my Entourage is setup and I can send emails to the same recipients fine from there.
I am sending out some newsletters, but am getting bounce backs with the following error:
Your message was rejected by <isp.name.here> for the following reason:
mail server permanently rejected message (#5.3.0)
I can send via my normal email application to these same people without...